Main Article Content

Abstract

Cervical cancer remains one of the leading causes of death among women in Asia, with low coverage of
Human Papillomavirus (HPV) vaccination in many countries. This low coverage is closely related to
educational barriers that have not been fully addressed. This study aims to identify barriers to HPV vaccination
education among adolescents in Asian countries through a systematic review approach. Articles were searched
through four databases (Google Scholar, PubMed, ScienceDirect, and GARUDA) using a combination both in
Indonesian language and English keywords with the Boolean search method. Selection followed the PRISMA
2020 guidelines with inclusion criteria of publications from 2015 to 2025, either in Indonesian language or
English, and available in full text, while exclusion criteria included literature review articles, irrelevance to
HPV vaccination in adolescents, or not originating from Asian countries. From the 62 articles found, 6 articles
met the criteria and were analyzed further. The results showed that the main barriers included low knowledge
among adolescents, lack of support from health workers, and misperceptions of risk. In addition, social stigma
and limited access to information were also significant barriers. Educational strategies involving schools,
families, and community leaders proved to be more effective when tailored to the cultural context. This study
concluded that an inclusive and contextual educational approach is essential to increase HPV vaccination
coverage among adolescents.

Keywords

HPV vaccination educational barriers adolescents

Article Details

How to Cite
Cordellia, N. N., Canttika, C., Dhiya’ulhaq, J. F., Sugiyarto, M. A. and Ariyanto, J. (2025) “Systematic Review: Barriers for Adolescent HPV Vaccination Education in Asian Countries”, Miracle Journal of Public Health , 8(2), pp. 166-175. doi: 10.36566/mjph.v8i2.470.

References

  1. 1. Hoang Dang Phan N, Thanh Nguyen T, Thanh Vo N, Tuyet Thi Le T, Bao Hoang Tran T, Kim Truong P, et al. Epidemiology, Incidence, Mortality of Cervical Cancer in Southeast Asia and their Relationship: An Update Report. Asian J Pharm Res Heal Care. 2020;12(3):1–5.
  2. 2. Rahmat F, Kuan JY, Hajiman Z, Shakrin NNSM, Roos NAC, Mustapa M, et al. Human Papillomavirus (HPV) Prevalence and Type Distribution in Urban Areas of Malaysia. Asian Pacific J Cancer Prev. 2021;22(9):2969–75.
  3. 3. Canfell K, Kim JJ, Brisson M, Keane A, Simms KT, Caruana M, et al. Mortality Impact of Achieving WHO Cervical Cancer Elimination Targets: A Comparative Modelling Analysis in 78 Low-income and Lower-middle-income Countries. Lancet. 2020;395(10224):591–603.
  4. 4. Yagi A, Ueda Y, Oka E, Nakagawa S, Kimura T. Human Papillomavirus Vaccination by Birth Fiscal Year in Japan. JAMA Netw open. 2024;7(7):e2422513.
  5. 5. Wijayanti KE, Schütze H, MacPhail C. Parents’ Attitudes, Beliefs and Uptake of the School-based Human Papillomavirus (HPV) Vaccination Program in Jakarta, Indonesia – A Quantitative Study. Prev Med Reports [Internet]. 2021;24:101651. Available from: https://doi.org/10.1016/j.pmedr.2021.101651
  6. 6. Setiawan D, Ramadani P, Lianawati L, Galistiani GF. HPV Vaccination Program in Indonesia: Effectiveness, Dose, Scale-Up Costs, Future Prospects, and Policy Recommendations. Asian Pac J Cancer Prev. 2025;26(2):421–34.
  7. 7. Susanto T, Rif’ah EN, Susumaningrum LA, Rahmawati I, Yunanto RA, Evayanti NLP, et al. Human Papillomavirus Vaccine Acceptability among Healthcare Workers, Parents, and Adolescent Pupils: A pilot Study in Public Health Centers of Bali, Indonesia. Germs. 2020;10(3):184–94.
  8. 8. Lismidiati W, Emilia O, Widyawati W. Human Papillomavirus (HPV) Health Savings as an Alternative Solution: HPV Vaccination Behavior in Adolescents. Asian Pacific J Cancer Prev. 2021;22(2):471–6.
  9. 9. Tran NT, Phan TNT, Pham TT, Le TT, Le HM, Nguyen DT, et al. Urban-rural Disparities in Acceptance of Human Papillomavirus Vaccination among Women in Can Tho, Vietnam. Ann di Ig Med Prev e di Comunita. 2023;35(6):641–59.
  10. 10. Ueda Y. Epidemiology of Cervical Cancer and HPV Infection in Asia and Oceania. J Obstet Gynaecol Res [Internet]. 2024;50(S1):31–41. Available from: http://scioteca.caf.com/bitstream/handle/123456789/1091/RED2017-Eng-8ene.pdf?sequence=12&isAllowed=y%0Ahttp://dx.doi.org/10.1016/j.regsciurbeco.2008.06.005%0Ahttps://www.researchgate.net/publication/305320484_SISTEM_PEMBETUNGAN_TERPUSAT_STRATEGI_MELESTARI.
  11. 11. World Health Organization. World Health Organization. 2024. Human Papillomavirus and Cancer. Available from: https://www.who.int/news-room/fact-sheets/detail/human-papilloma-virus-and-cancer
  12. 12. Suryoadji KA, Ridwan, Alifaturrasyid Syafaatullah FK. Vaksin HPV Sebagai Strategi Pencegahan Kanker Serviks Di Indonesia. J Ilm Mhs Kedokt Indones [Internet]. 2022;10(1):hal 114-120. Available from: https://bapin-ismki.e-journal.id/jimki/article/download/521/249
  13. 13. Woestenberg PJ, King AJ, Van Benthem BHB, Donken R, Leussink S, Van Der Klis FRM, et al. Bivalent Vaccine Effectiveness Against Type-Specific HPV Positivity: Evidence for Cross-Protection Against Oncogenic Types among Dutch STI Clinic Visitors. J Infect Dis. 2018;217(2):213–22.
  14. 14. Wantini NA, Indrayani N. Low Willingness to Participate in HPV Vaccination among Adolescent Girls. J Kebidanan Indones [Internet]. 2020;11(1):69–78. Available from: https://www.jurnal.stikesmus.ac.id/index.php/JKebIn/article/view/327
  15. 15. Bloom BS. Taxonomy of Educational Objectives. Comittee of College and University of University Examiners. 1956.
  16. 16. Nency A, Muslimah AZ, Wulandari V, Hidayah N, Ngawo AV, Putri FF. Kenali dan Cegah Kanker Serviks pada Wanita Usia Subur. J Pengabdi Masy Indones Maju. 2024;5(2):53–6.
  17. 17. Siu JYM, Fung TKF, Leung LHM. Social and Cultural Construction Processes Involved in HPV Vaccine Hesitancy among Chinese Women: A Qualitative Study. Int J Equity Health. 2019;18(1):1–18.
  18. 18. Wong LP, Wong PF, Hashim MMAAM, Han L, Lin Y, Hu Z, et al. Multidimensional Social and Cultural Norms influencing HPV Vaccine Hesitancy in Asia. Hum Vaccines Immunother [Internet]. 2020;16(7):1611–22. Available from: https://doi.org/10.1080/21645515.2020.1756670
  19. 19. McKenzie AH, Shegog R, Savas LS, Healy CM, Shay LA, Preston S, et al. Parents’ Stigmatizing Beliefs about the HPV Vaccine and Their Association with Information Seeking Behavior and Vaccination Communication Behaviors. Hum Vaccines Immunother [Internet]. 2023;19(1):1–9. Available from: https://doi.org/10.1080/21645515.2023.2214054
  20. 20. Chua GT, Ho FK, Tung KT, Wong RS, Cheong KN, Yip PS, et al. Sexual Behaviors and Intention for Cervical Screening among HPV-vaccinated Young Chinese Females. Vaccine [Internet]. 2020;38(5):1025–31. Available from: https://doi.org/10.1016/j.vaccine.2019.11.044
  21. 21. Chanprasertpinyo W, Rerkswattavorn C. Human Papillomavirus (HPV) Vaccine Status and Knowledge of Students at A University in Rural Thailand. Heliyon [Internet]. 2020;6(8):e04625. Available from: http://dx.doi.org/10.1016/j.heliyon.2020.e04625
  22. 22. Shaikh MY, Hussaini MF, Narmeen M, Effendi R, Paryani NS, Ahmed A, et al. Knowledge, Attitude, and Barriers Towards Human Papillomavirus (HPV) Vaccination Among Youths of Karachi, Pakistan. Cureus. 2019;11(11).
  23. 23. Sutjipto AM, Pinariya JM. Pengenalan Vaksinasi Hpv Oleh Koalisi Indonesia Cegah Kanker Serviks Dengan Pendekatan Teori Difusi Inovasi. WACANA J Ilm Ilmu Komun. 2019;18(2).
  24. 24. Zhao XL, Hu SY, Hu JW, Wang HH, Wen TM, Feng YS, et al. Tackling Barriers to Scale Up Human Papillomavirus Vaccination in China: Progress and The Way Forward. Infect Dis Poverty [Internet]. 2023;12(1):1–6. Available from: https://doi.org/10.1186/s40249-023-01136-6
  25. 25. Burney A, Zafar R. HPV Vaccination as a MOde of Cervical Cancer Prevention in Pakistan. South Asian J Cancer. 2023;12(1):51–2.
  26. 26. Purwahyuni NM, Rismawan M, Wulansari NT. Studi Deskriptif Hambatan Remaja dalam Melakukan Vaksinasi Human Papillomvirus (HPV) di SMA Negeri 1 Kediri. J Ris Kesehat Nasuonal. 2020;4(2):44–8.
  27. 27. Phongsamart W, Lou PJ, Sukarom I, Wu YH, Zaidi O, Du F, et al. Integrative Literature Review on Human Papillomavirus Vaccination Recommendations in National Immunization Programs in Select Areas in the Asia-Pacific Region. Hum Vaccines Immunother [Internet]. 2024;20(1):1–6. Available from: https://doi.org/10.1080/21645515.2024.2362449
  28. 28. Liu W, Jing L, Huang X, Huang H, Jiang KL, Lu W. Cost-effectiveness of Cervical Cancer Screening and HPV Vaccination: A Markov Model from the Healthcare Payer Perspective. Front Public Heal. 2025;13(October):1–10.
  29. 29. Hidayati NR, Endarti D, Setiawan D. Cost-Utility Analysis of Expanding Human Papillomavirus Vaccination to Adult Women in Indonesia: A Markov Model Approach. Value Heal Reg Issues [Internet]. 2025;50:1–9. Available from: https://doi.org/10.1016/j.vhri.2025.101147
  30. 30. Mao Y, Zhao Y, Zhang L, Li J, Abdullah AS, Zheng P, et al. Frequency of Health Care Provider Recommendations for HPV Vaccination: A Survey in Three Large Cities in China. Front Public Heal. 2023;11(July):1–10.
  31. 31. Shao X, Lu X, Zhou W, Huang W, Lu Y. HPV Vaccination Behavior, Vaccine Preference, and Health Beliefs in Chinese Female Health Care Workers: A Nationwide Cross-Sectional Study. Vaccines. 2023;11:1–12.
  32. 32. Wang H, Liu F, Zhang H, Chen N, Wang C. Influential Factors and Willingness to Advocate for HPV Vaccination among Male Nursing Interns in China. BMC Nurs. 2024;23(1–9).