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Submitted
Apr 29, 2025
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May 27, 2025
Published
Jun 30, 2025
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Abstract

Nasopharyngeal cancer (NPC) is a squamous cell cancer that originates from the epithelial lining of the nasopharynx. The issue of salted fish consumption is a concern because the salt preservation process can produce carcinogenic nitrosamine compounds. The nitrosamine content is formed from the reaction between nitrite, nitrate, and secondary amines, which has the potential to cause cell changes to become malignant if consumed in the long term, especially from an early age. This study aimed to systematically review the consumption pattern of salted fish based on age, frequency of consumption, and its potential risk of NPC and to identify gaps in the results of previous studies. The method used was a systematic review by searching the literature on online databases such as Scopus, PubMed, ScienceDirect, and Garuda. A total of 126 articles were obtained, and 11 articles met the criteria. The results of the analysis showed that there are differences in salted fish consumption patterns based on age and frequency that may increase the risk of NPC, especially in individuals who started consuming in childhood and high amounts. This study highlights the need for further research that considers genetic aspects, types of salted fish, and processing methods in different regions to clarify the causal relationship.

Keywords

Risk factors salted fish nasopharyngeal cancer

Article Details

How to Cite
Syafira, S., Siregar, S. F. E., Saputra, D., Febriansyah, R. I. and Ariyanto, J. (2025) “Salted Fish Consumption Factors on the Incidence of Nasopharyngeal Cancer: A Systematic Review”, Miracle Journal of Public Health , 8(1), pp. 35-44. doi: 10.36566/mjph.v8i1.411.

References

  1. 1. Shah AB, Nagalli S. Nasopharyngeal Carcinoma [Internet]. StatPearls Publishing; 2024. https://pubmed.ncbi.nlm.nih.gov/32119475
  2. 2. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, dkk. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209–49.
  3. 3. Ferlay J, Ervik M, Lam F, Laversanne M, Colombet M, Mery L, dkk. Global Cancer Observatory: Cancer Today [Internet]. [dikutip 7 Maret 2025]. https://gco.iarc.who.int/today
  4. 4. Arohmah NK, Oyong, Prabowo RH. Gambaran Klinis dan Faktor Risiko Penderita Kanker Nasofaring. Conference on Innovation in Health, Accounting and Management Sciences (CIHAMS). 2020;1: 205–10.
  5. 5. Kurniasari FN, Harti LB, Ariestiningsih AD, Wardhani SO, Nugroho S. Buku Ajar Gizi dan Kanker. Universitas Brawijaya Press; 2017.
  6. 6. Zuhdi MA, Al-Munip, Daud. Upaya Pengelolaan Ikan Asin dalam Meningkatkan Pendapatan Nelayan. Zabags International Journal of Engagement. 2023;1(1):22–7.
  7. 7. Dawolo AP, Utama DS, Kasim BI. Profil Klinis Karsinoma Nasofaring di Departemen THTKL RSUP Dr. Mohammad Hoesin Palembang Tahun 2014–2015. Majalah Kedokteran Sriwijaya. 2017;49: 1–9.
  8. 8. Sitepu SM, Hutagalung SB, Simanullang F. Hubungan Kebiasaan Konsumsi Ikan Asin dengan Terjadinya Karsinoma Nasofaring dan Non Karsinoma Nasofaring di RSU Vina Estetica Tahun 2022-2023. Medical Methodist Journal (Medimeth). 2023;1(4):27–34.
  9. 9. Putera I, Ramadhan MG, Anindya S, Sutanto NR, Kurniawan A, Hosea FN, dkk. Relationship Between Salted Fish Consumption and Nasopharyngeal Carcinoma: An Evidence-based Case Report. Acta Med Indones [Internet]. 2015;47(1):72–7. https://www.actamedindones.org/index.php/ijim/article/view/13
  10. 10. Nuaba IGA, Nalle TS, Weta IW. Correlation of Cigarette Smoking and Salted Fish Consumption with Nasopharyngeal Carcinoma and Its Clinical Stage in ORL-HNS Outpatient, Sanglah General Hospital. International Journal of Nasopharyngeal Carcinoma [Internet]. 2020;2(4):103–7. https://garuda.kemdikbud.go.id/documents/detail/2438700
  11. 11. Chen Y, Chang ET, Liu Q, Cai Y, Zhang Z, Chen G, dkk. Environmental Factors for Epstein-Barr Virus Reactivation in a High-Risk Area of Nasopharyngeal Carcinoma: A Population-Based Study. Open Forum Infect Dis. 1 Mei 2022;9(5).
  12. 12. Ban EZ, Lye MS, Chong PP, Yap YY, Lim SYC, Rahman HA. Haplotype CGC from XPD, hOGG1 and ITGA2 polymorphisms increases the risk of nasopharyngeal carcinoma in Malaysia. PLoS One. 1 November 2017;12(11).
  13. 13. Kasim M, Tan’im, Pebriyani U, Aprillya E. Konsumsi Ikan Asin dan Daging Asap dengan Kejadian Karsinoma Nasofaring. Jurnal Kesehatan Ilmiah Sandi Husada [Internet]. 2020;9(1):62–71. https://akper-sandikarsa.e-journal.id/JIKSH
  14. 14. Sulaksana MA, Kadriyan H. Characteristics and Risk Factors of Patients with Nasopharyngeal Carcinoma in West Nusa Tenggara Hospital. International Journal of Nasopharyngeal Carcinoma [Internet]. 2019;1(3):83–5. https://garuda.kemdikbud.go.id/documents/detail/1661044
  15. 15. Nathania N, Dewi YA, Permana AD. Profile of Head Neck Cancer Patients from 2013-2018 at Dr.Hasan Sadikin General Hospital Bandung. Oto Rhino Laryngologica Indonesiana. 2020;50(2):141–5.
  16. 16. Barrett D, Ploner A, Chang ET, Liu Z, Zhang CX, Liu Q, dkk. Past and Recent Salted Fish and Preserved Food Intakes are Weakly Associated with Nasopharyngeal Carcinoma Risk in Adults in Southern China. Journal of Nutrition. 1 September 2019;149(9):1596–605.
  17. 17. Rizal NI, Utama DS. Role of Dietary Intake as Risk Factor for Nasopharyngeal Carcinoma in Muhammadiyah Hospital Palembang June 2017-September 2018. International Journal of Nasopharyngeal Carcinoma [Internet]. 2019;1(3):105–6. https://garuda.kemdikbud.go.id/documents/detail/1661042
  18. 18. Fitria EZC, Rumastika NS, Wulandari P. Hubungan Faktor Risiko dengan Kejadian Karsinoma Nasofaring (KNF) di RSD dr. Soebandi Periode January 2017–Maret 2019. Journal of Agromedicine and Medical Sciences. 2020;6(3):130–6.
  19. 19. Lye MS, Visuvanathan S, Chong PP, Yap YY, Lim CC, Ban EZ. Homozygous Wildtype of XPD K751Q Polymorphism is Associated with Increased Risk of Nasopharyngeal Carcinoma in Malaysian Population. PLoS One. 18 Juni 2015;10(6).
  20. 20. Kurnia B, Fadhlia, Setiani L, Juniar, Mulya RC. Young Woman with Early Stage Nasopharyngeal Carcinoma: A Rare Case. International Journal of Nasopharyngeal Carcinoma. 2021;3(1):28–30.
  21. 21. Romdhoni AC. Buku Ajar Karsinoma Nasofaring. Airlangga University Press; 2021.
  22. 22. Pulungan AF. Penetapan Kadar Senyawa Nitrit yang Terdapat pada Ikan Asin dengan Menggunakan Metode Spektrofotmetri UV-Vis. JURNAL ILMIAH FARMASI IMELDA. 2020;4(1):7–10.
  23. 23. Imtihan, Irwandi. Analisis Faktor-Faktor yang Mempengaruhi Permintaan Ikan Asin Laut di Kota Padang. Menara Ilmu: Jurnal Penelitian dan Kajian Ilmiah. 2020;14(1):63–71.
  24. 24. Raditya ZA, Fariadi H, Nurmalia A. Analysis of Factors Affecting the Demand for Salted Fish on the Malabero Coast of Bengkulu City. Multidisciplinary Journals. 2024;1: 235–44.
  25. 25. Haque E, Khanom S, Afrad SI, Barau AA, Rafiquzzaman SM. Consumer Preference for Sea Fish Consumption in Dhaka City of Bangladesh. 2019. https://banglajol.info/index.php/AGRIC/article/view/44695
  26. 26. Romdhoni AC. Bunga Rampai Karsinoma Nasofaring Diagnosis dan Terapi Terkini. Airlangga University Press; 2021.
  27. 27. Hartanti L, Nurdiansyah SI. Penerapan Teknik Pengeringan Ikan Laut secara Higienis kepada Masyarakat Pesisir Pulau Karimata. Jurnal Pengabdian kepada Masyarakat Nusantara (JPkMN). 2024;5(2):2214–9.
  28. 28. Keputusan Menteri Kelautan dan Perikanan Nomor 8/KEPMEN-KP/2014 Tahun 2014 tentang Pemberlakuan Penerapan Standar Nasional Indonesia Produk Perikanan [Internet]. 8/KEPMEN-KP/2014 2014. https://peraturan.bpk.go.id/Details/159912/kepmen-kkp-no-8kepmen-kp2014-tahun-2014
  29. 29. Peraturan Menteri Kelautan dan Perikanan Nomor 5 Tahun 2021 tentang Usaha Pengolahan Ikan [Internet]. 5 2021. https://peraturan.bpk.go.id/Details/165802/permen-kkp-no-5-tahun-2021
  30. 30. Kadriyan H, Yudhanto D, Cahyawati TD, Putri R NA, Wedayani N. Pengenalan Gejala Nasopharyngeal Cancer pada Populasi Beresiko di Lombok Utara 2021 pada saat Pandemi Covid19. Jurnal Pengabdian Magister Pendidikan IPA. 15 September 2022;5(3):231–4.
  31. 31. Sulaiman E. Nasopharyngeal Carcinoma Patient Characteristics at Sayang General Hospital Cianjur West Java. Dalam: Proceedings of the 2nd Global Health and Innovation in conjunction with 6th ORL Head and Neck Oncology Conference (ORLHN 2021). Atlantis Press International B. V.; 2022. hlm. 314.
  32. 32. Ren JT, Li MY, Wang XW, Xue WQ, Ren ZF, Jia WH. Potential Factors Associated with Clinical Stage of Nasopharyngeal Carcinoma at Diagnosis: A Case-Control Study. Chin J Cancer. 2017;36(1):71.
  33. 33. Rosmawati DI, Indrasari SR, Herdini C, Fles R, Tan IB, Fidianingsih I. Efektivitas Seminar untuk Meningkatkan Pengetahuan tentang Kewaspadaan Kanker Nasofaring bagi Tenaga Kesehatan di Kabupaten Gunungkidul. Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat. 2023;2(2):71–7.
  34. 34. Wedayani AAAN, Putri NA, Kadriyan H, Yuliani EA, Hasbi N, Ayunda RD, dkk. Edukasi Pengenalan Faktor Risiko serta Tanda dan Bahaya dari Keganasan pada Nasofaring di RSUDP NTB Tahun 2023. Jurnal Pengabdian Magister Pendidikan IPA. 2023;6(2):17–20.